Interferon β-1a in relapsing multiple sclerosis: four-year extension of the European IFNβ-1a Dose-C omparison Study

Background: Multiple sclerosis (MS) is a chronic disease requiring long-term monitoring of treatment. Objective: To assess the four-year clinical efficacy of intramuscular (IM) IFNb-1a in patients with relapsing MS from the European IFNb-1a Dose-C omparison Study. Methods: Patients who completed 36 months of treatment (Part 1) of the European IFNb-1a Dose-C omparison Study were given the option to continue double-blind treatment with IFNb-1a 30 mcg or 60 mcg IM once weekly (Part 2). Analyses of 48-month data were performed on sustained disability progression, relapses, and neutralizing antibody (NA b) formation. Results: O f 608/802 subjects who completed 36 months of treatment, 493 subjects continued treatment and 446 completed 48 months of treatment and follow-up. IFNb-1a 30 mcg and 60 mcg IM once weekly were equally effective for up to 48 months. There were no significant differences between doses over 48 months on any of the clinical endpoints, including rate of disability progression, cumulative percentage of patients who progressed (48 and 43, respectively), and annual relapse rates; relapses tended to decrease over 48 months. The incidence of patients who were positive for NAbs at any time during the study was low in both treatment groups. Conclusion: C ompared with 60-mcg IM IFNb-1a once weekly, a dose of 30 mcg IM IFNb-1a once weekly maintains the same clinical efficacy over four years

The Corinth Rift Laboratory, Greece (CRL): A Multidisciplinary Near Fault Observatory (NFO) on a Fast Rifting System

The western rift of Corinth (Greece) is one of the most active tectonic structures of the euro-mediterranean area. Its NS opening rate is 1.5 cm/yr ( strain rate of 10-6/yr) results into a high microseismicity level and a few destructive, M>6 earthquakes per century, activating a system of mostly north dipping normal faults. Since 2001, monitoring arrays of the European Corinth Rift Laboratory (CRL, www.crlab.eu) allowed to better track the mechanical processes at work, with short period and broad band seismometers, cGPS, borehole strainmeters, EM stations, …). The recent (300 kyr) tectonic history has been revealed by onland (uplifted fan deltas and terraces) and offshore geological studies (mapping, shallow seismic, coring), showing a fast evolution of the normal fault system. The microseismicity, dominated by swarms lasting from days to months, mostly clusters in a layer 1 to 3 km thick, between 6 and 9 km in depth, dipping towards north, on which most faults are rooting. The diffusion of the microseismicity suggests its triggering by pore pressure transients, with no or barely detected strain. Despite a large proportion of multiplets, true repeaters seem seldom, suggesting a minor contribution of creep in their triggering, although transient or steady creep is clearly detected on the shallow part of some majors faults. The microseismic layer may thus be an immature, downward growing detachment, and the dominant rifting mechanism might be a mode I, anelastic strain beneath the rift axis , for which a mechanical model is under development. Paleoseismological (trenching, paleoshorelines, turbidites), archeological and historical studies completed the catalogues of instrumental seismicity, motivating attempts of time dependent hazard assessment. The Near Fault Observatory of CRL is thus a multidisciplinary research infrastructure aiming at a better understanding and modeling of multiscale, coupled seismic/aseismic processes on fault systems.Grant for Researchers (CC) ID 188753

A layered model of the upper crust in the Aigion region of Greece, inferred from arrival times of the 2001 earthquake sequence

International audienceThe western part of the Gulf of Corinth attracts attention due to its seismically active fault system and considerable seismic hazard. Detailed studies of the seismic activity of the region have been carried out especially as part of the so-called Corinth Rift Laboratory (CRL) Project. For standard earthquake locations, the CRL uses the HYPO algorithm and a special structural model that is composed of homogeneous layers (Rigo et al., 1996). This model was derived from a passive seismic experiment in a broader area around the western part of the Gulf. A significant part of the seismic activity is concentrated close to the town of Aigion, which was damaged by a strong earthquake in 1995. A sequence of smaller earthquakes occurred to the south of this town in the year 2001. In the present paper, we have used this sequence to derive an improved structural model for the region in the vicinity of the town of Aigion. This new model is based on the minimization of travel-time residuals. In particular, we used arrival times from a subset of 88 events recorded by at least 5 stations of the southern part of the CRL network, had magnitudes of over 2.3, and were recorded at the nearest station (station code AIO). A variant of the method of conjugate gradients has been used for this purpose. In comparison with the model derived by Rigo et al. (1996), the new model is characterized by a higher νP/νS velocity ratio and by higher velocities to a depth of about 7 km. The new model was derived with the aim to get more accurate locations of future events in the vicinity of the town of Aigio

Methodology for earthquake rupture rate estimates of fault networks: example for the western Corinth rift, Greece

Modeling the seismic potential of active faults is a fundamental step of probabilistic seismic hazard assessment (PSHA). An accurate estimation of the rate of earthquakes on the faults is necessary in order to obtain the probability of exceedance of a given ground motion. Most PSHA studies consider faults as independent structures and neglect the possibility of multiple faults or fault segments rupturing simultaneously (fault-to-fault, FtF, ruptures). The Uniform California Earthquake Rupture Forecast version 3 (UCERF-3) model takes into account this possibility by considering a system-level approach rather than an individual-fault-level approach using the geological, seismological and geodetical information to invert the earthquake rates. In many places of the world seismological and geodetical information along fault networks is often not well constrained. There is therefore a need to propose a methodology relying on geological information alone to compute earthquake rates of the faults in the network. In the proposed methodology, a simple distance criteria is used to define FtF ruptures and consider single faults or FtF ruptures as an aleatory uncertainty, similarly to UCERF-3. Rates of earthquakes on faults are then computed following two constraints: the magnitude frequency distribution (MFD) of earthquakes in the fault system as a whole must follow an a priori chosen shape and the rate of earthquakes on each fault is determined by the specific slip rate of each segment depending on the possible FtF ruptures. The modeled earthquake rates are then compared to the available independent data (geodetical, seismological and paleoseismological data) in order to weight different hypothesis explored in a logic tree.The methodology is tested on the western Corinth rift (WCR), Greece, where recent advancements have been made in the understanding of the geological slip rates of the complex network of normal faults which are accommodating the ∼ 15 mm yr−1 north–south extension. Modeling results show that geological, seismological and paleoseismological rates of earthquakes cannot be reconciled with only single-fault-rupture scenarios and require hypothesizing a large spectrum of possible FtF rupture sets. In order to fit the imposed regional Gutenberg–Richter (GR) MFD target, some of the slip along certain faults needs to be accommodated either with interseismic creep or as post-seismic processes. Furthermore, computed individual faults' MFDs differ depending on the position of each fault in the system and the possible FtF ruptures associated with the fault. Finally, a comparison of modeled earthquake rupture rates with those deduced from the regional and local earthquake catalog statistics and local paleoseismological data indicates a better fit with the FtF rupture set constructed with a distance criteria based on 5 km rather than 3 km, suggesting a high connectivity of faults in the WCR fault system